Krzysztof P. Mikolajczyk

This study develops glycoengineered small extracellular vesicles (sEVs) decorated with Gb3 to neutralize Shiga toxin 1 subunit B, showing effective binding and reduced toxin activity without harming cell viability.

This study compares the activity and glycosylation of human Gb3/CD77 synthase produced in insect and human cells, showing host-specific glycosylation and tag position effects on enzyme activity.

This study creates glycoengineered CHO-Lec2 cells lacking B4GALT5 to study Shiga toxin receptors, finding they bind neither Stx1B nor Stx2B and show resistance to Stx1 holotoxin.

This paper develops exosome-based agents that bind and neutralize Shiga toxin type 1, showing protective effects in cell experiments.

This study investigates A4galt acceptor specificity by analyzing its dimerization with other GTs and using structural prediction to understand specificity toward GSLs and GPs.