Chuanhe Yu

REPLAY automates DNA replication timing analysis from Repli-seq data, providing a reproducible and user-friendly tool without requiring programming expertise.

This study shows that defective parental histone transfer in budding yeast reduces homologous recombination frequency, likely due to increased free histones.

The paper shows DNA polymerases δ and ε associate differently with active and stalled replication forks, suggesting distinct roles in DNA synthesis resumption after stress.