Zhiguo Zhang

Chromatin architecture sets origin licensing capacity

The paper shows that chromatin architecture limits replication origin licensing capacity in budding yeast by restricting helicase loading through Isw2-dependent nucleosome repositioning.

Elucidation and Pharmacologic Targeting of Master Regulator Dependencies in Coexisting Diffuse Midline Glioma Subpopulations

The paper identifies master regulator dependencies in coexisting diffuse midline glioma subpopulations and shows that combination therapy targeting these regulators improves survival in vivo.

Mcm2 promotes stem cell differentiation via its ability to bind H3-H4

This study shows Mcm2 promotes stem cell differentiation by binding histones and regulating chromatin accessibility at bivalent domains.

Ezh2-dependent epigenetic reprogramming controls a developmental switch between modes of gastric neuromuscular regulation

The paper shows Ezh2-mediated epigenetic repression drives the conversion of gastric interstitial cells of Cajal into fibroblast-like cells during development, with reversible effects upon Ezh2 inhibition.

Both DNA Polymerases δ and ε Contact Active and Stalled Replication Forks Differently

The paper shows DNA polymerases δ and ε associate differently with active and stalled replication forks, suggesting distinct roles in DNA synthesis resumption after stress.