Immune-mediated Engagement of T Regulatory Cells with Tumor Cells Results in Trogocytosis and Tumor Cell Killing.
Amy K. Erbe, Arika S. Feils, Anqi Gao, Sabrina N. VandenHeuvel, Simon Boyenga, Alina A. Hampton, Mackenzie Heck, Jen Zaborek, Daniel Spiegelman, Noah W. Tsarovsky, Anna Hoefges, Alexander A. Pieper, Peter M. Carlson, Mildred A. R. Felder, Ravi B. Patel, , Paul M. Sondel
The paper shows CD4 T regulatory cells can kill tumor cells through trogocytosis after immunocytokine treatment in a melanoma model.
bioRxiv · Dec 23, 2025 · PreprintCancer Biology