This study identifies DNA methylation signatures associated with gestational diabetes mellitus across pregnancy stages and discovers new genes potentially linked to GDM and related diseases.

Journal of Translational Medicine · Dec 24, 2025Peer-reviewedGenetic & Genomic Medicine

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations

Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A. J. Smit, Zhe Wang, Kruthika Raman Iyer, Austin T. Hilliard, Jeffrey Haessler, Ran Tao, K. Alaine Broadaway, Yujie Wang, Nikita V. Pozdeyev, Frederik Filip Stæger, Chaojie Yang, Brett R. Vanderwerff, , Burcu F. Darst

medRxiv · Feb 15, 2025 · PreprintGenetic & Genomic Medicine

Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E. Graham, Yuxuan Wang, Ida L. Surakka, Shweta Ramdas, Xiang Zhu, Shoa L. Clarke, Konain Fatima Bhatti, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Greg J. M. Zajac, Kuan-Han Wu, Ιωάννα Ντάλλα, , Pala Mauro

This study identifies 118 candidate causal genes and 21 novel lipid loci on the X chromosome through a multi-ancestry meta-analysis of blood lipid levels, revealing sex-biased effects and pleiotropy with cardiovascular and hormonal traits.

Genome biology · Dec 27, 2022Peer-reviewedGenetic & Genomic Medicine

Twelve-year changes in protein profiles in patients with and without gastric bypass surgery

Noha A. Yousri, Rudolf Engelke, Hina Sarwath, Rodrick D. McKinlay, Steven C. Simper, Ted D. Adams, Frank Martin Schmidt, Karsten Suhre, Steven C. Hunt

The paper measures 12-year changes in blood-circulating proteins in patients with and without gastric bypass surgery, finding long-term associations with BMI and lipid levels.

medRxiv · Aug 13, 2020 · PreprintGenetic & Genomic Medicine