This study performs a genome-wide association study using mass spectrometry proteomics to identify pQTLs, finding that epitope effects may affect some affinity proteomics results while confirming others.

bioRxiv · May 27, 2024 · PreprintGenomics

Nanoparticle Enrichment Mass-Spectrometry Proteomics Identifies Protein Altering Variants for Precise pQTL Mapping

Karsten Suhre, Guhan Ram Venkataraman, Harendra Guturu, Anna Halama, Nisha Stephan, Gaurav Thareja, Hina Sarwath, Khatereh Motamedchaboki, Margaret K. R. Donovan, Asim S. Siddiqui, Serafim Batzoglou, Frank Schmidt

This study uses mass spectrometry proteomics to identify protein altering variants and map pQTLs, confirming target specificity and identifying novel variants not accessible by affinity proteomics.

Nature Communications · Feb 2, 2024Peer-reviewedGenomics

Twelve-year changes in protein profiles in patients with and without gastric bypass surgery

Noha A. Yousri, Rudolf Engelke, Hina Sarwath, Rodrick D. McKinlay, Steven C. Simper, Ted D. Adams, Frank Martin Schmidt, Karsten Suhre, Steven C. Hunt

The paper measures 12-year changes in blood-circulating proteins in patients with and without gastric bypass surgery, finding long-term associations with BMI and lipid levels.

medRxiv · Aug 13, 2020 · PreprintGenetic & Genomic Medicine

Connecting genetic risk to disease endpoints through the human blood plasma proteome

Karsten Suhre, Matthias Arnold, Aditya Mukund Bhagwat, Richard J. Cotton, Rudolf Engelke, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Annika Wahl, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A. El-Din Selim, Dennis O. Mook‐Kanamori, , Johannes Graumann

The paper performs a GWAS on blood plasma proteome data from two cohorts to identify SNP-protein associations linked to various diseases and creates a genome-proteome network and web tool for analysis.

Nature Communications · Feb 27, 2017Peer-reviewedGenetics