Raphaël Leman

This study establishes patient-derived ovarian cancer organoids that mimic tumor characteristics and drug responses, showing potential for precision medicine.

The paper evaluates splicing prediction methods on 56 clinically validated variants, finding some methods match or exceed SpliceAI's performance but highlighting ongoing challenges in accuracy.

The paper estimates that 15-18% of canonical GT 5' splice sites can generate wild-type transcripts when mutated to GC, with implications for disease and splicing mechanisms.