Laurent Poulain

This study uses patient-derived tumor organoids to predict HNSCC patient outcomes, finding strong associations between organoid responses to cisplatin and X-rays and clinical prognosis.

The paper shows that MET exon 14 skipping mutations eliminate the pro-apoptotic function of MET, converting it from a tumor suppressor to an oncogenic driver in lung adenocarcinomas.

This study establishes patient-derived ovarian cancer organoids that mimic tumor characteristics and drug responses, showing potential for precision medicine.