Author

Elise S. Bruguera

ORCID 0000-0003-1983-3013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander DerryiD· 1 shared Alexander W. RivesiD· 1 shared Allan dos Santos CostaiD· 1 shared Alvin HsuiD· 1 shared Anthony W. GoeringiD· 1 shared Ashton Trotman‐GrantiD· 1 shared Bryan Z. Wu· 1 shared Daniel S. LiuiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Alexander DerryORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 4, 2026

Language Modeling Materializes a World Model of Protein Biology

Salvatore Candido, Thomas Hayes, Alexander Derry…·Alexander W. Rives

The paper uses language modeling to create a comprehensive representation of protein biology, enabling structure prediction and discovery of high-affinity protein interactions.

35 citations

protein sequencedeep learning

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BiochemistrybioRxivPreprintFeb 3, 2024

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Elise S. Bruguera, Jacob P. Mahoney, William I. Weis

This study identifies Tetraspanin12 as a co-receptor that directly binds Norrin to enhance its signaling through the Wnt/β-catenin pathway by capturing Norrin before it interacts with Fzd4.

DOI 10.1101/2024.02.03.578714

mouseproteomics

𝕏 PostBluesky