William I. Weis

Mechanical opening of the αE-catenin M-region gates afadin condensation in cardiomyocytes

The paper shows that mechanical force opens the E-catenin M-region, enabling afadin condensate formation at high-load adherens junctions in cardiomyocytes.

Phosphorylation-dependent binding of the Adenomatous Polyposis Coli protein to β-TrCP1 regulates β-catenin destruction

This study identifies phosphorylation-dependent binding of APC to β-TrCP1 as a mechanism regulating β-catenin destruction in Wnt signaling.

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

This study identifies Tetraspanin12 as a co-receptor that directly binds Norrin to enhance its signaling through the Wnt/β-catenin pathway by capturing Norrin before it interacts with Fzd4.