Author

Siyu Zhu

University of WashingtonORCID 0000-0003-2001-0946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:diffusion model· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Brian CoventryiD· 2 shared David A. BakeriD· 2 shared Alex KangiD· 1 shared Amir MotmaeniD· 1 shared Andrew C. LuiD· 1 shared Anne PinkiD· 1 shared Asim K. BeraiD· 1 shared Carolina MölleriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Brian CoventryORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 2, 2026

Integrin-independent Tie2 activation using de novo designed proteins

Clara McCurdy, Yan Ting Zhao, Saurav Kumar…·Hannele Ruohola‐Baker

This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.

DOI 10.64898/2026.05.01.718274

mousedeep learning

𝕏 PostBluesky

BiochemistrybioRxivPreprintSep 29, 2025

De novo design of phosphotyrosine peptide binders

Magnus S. Bauer, Jason Z. Zhang, Kejia Wu…·David A. Baker

This paper introduces RFD2-MI, a deep learning framework for designing phosphotyrosine peptide binders, showing high specificity and affinity for phosphorylated targets.

4 citations

protein structuredeep learning

𝕏 PostBluesky