Structural insights as to how iron-loaded siderophores are imported into Mycobacterium tuberculosis by IrtAB
Shan Sun, Yan Gao, Xiaolin Yang, Xiuna Yang, Tianyu Hu, Jingxi Liang, Zhiqi Xiong, Pengxuan Ren, Fang Bai, Luke W. Guddat, Haitao Yang, Zihe Rao, Bing Zhang
This study reports the structure of Mtb IrtAB in different states, revealing its mechanism for importing iron-loaded siderophores through ATP-driven conformational changes.
bioRxiv · Jan 11, 2022 · PreprintMolecular Biology