Haitao Yang

Structural basis of virion assembly in the Mycobacterium tuberculosis-infecting mycobacteriophage SWU1

This study determines the atomic structure of mycobacteriophage SWU1 using cryo-EM, revealing key architectural features critical for virion assembly and infection.

Structural basis for loop-dependent inhibition by AcrIIC1 anti-CRISPR proteins

This study identifies a loop-dependent inhibitory mechanism in AcrIIC1 anti-CRISPR proteins, showing how a unique loop enhances inhibition by disrupting sgRNA binding and R-loop maturation.

A parabrachial-hypothalamic parallel circuit governs cold defense in mice

The paper identifies a parabrachial-hypothalamic parallel circuit in mice that governs cold defense by activating thermogenesis and other responses.

Structural insights as to how iron-loaded siderophores are imported into Mycobacterium tuberculosis by IrtAB

This study reports the structure of Mtb IrtAB in different states, revealing its mechanism for importing iron-loaded siderophores through ATP-driven conformational changes.

Parabrachial neuron types categorically encode thermoregulation variables during heat defense

The paper identifies two distinct neuron types in the lateral parabrachial nucleus that encode thermoregulation variables during heat defense.