Author

Pengxuan Ren

ShanghaiTech UniversityORCID 0000-0001-6475-3974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Fang BaiiD· 2 shared Bing ZhangiD· 1 shared Haitao YangiD· 1 shared Jingxi LiangiD· 1 shared Junhong Yuan· 1 shared Lin WangiD· 1 shared Luke W. GuddatiD· 1 shared Qi HaniD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Fang BaiORCID

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2 papers

Recent·Most cited

PhenoScreen: A Dual-Space Contrastive Learning Framework-based Phenotypic Screening Method by Linking Chemical Perturbations to Cellular Morphology

Shihang Wang, Qi Han, Weichen Qin, Lin Wang, Junhong Yuan, Yiqun Zhao, Pengxuan Ren, Yunze Zhang, Yilin Tang, Ruifeng Li, Zongquan Li, Wenchao Zhang, Shenghua Gao, Fang Bai

PhenoScreen predicts compound-induced phenotypic changes by linking chemical space to cellular morphology using contrastive learning, showing effectiveness in osteosarcoma and rhabdomyosarcoma.

bioRxiv · Oct 23, 2024 · PreprintBioinformatics

Structural insights as to how iron-loaded siderophores are imported into Mycobacterium tuberculosis by IrtAB

Shan Sun, Yan Gao, Xiaolin Yang, Xiuna Yang, Tianyu Hu, Jingxi Liang, Zhiqi Xiong, Pengxuan Ren, Fang Bai, Luke W. Guddat, Haitao Yang, Zihe Rao, Bing Zhang

This study reports the structure of Mtb IrtAB in different states, revealing its mechanism for importing iron-loaded siderophores through ATP-driven conformational changes.

bioRxiv · Jan 11, 2022 · PreprintMolecular Biology