LRP1 and SORL1 regulate tau internalization and degradation and enhance tau seeding
Joanna M. Cooper, Aurélien Lathuilière, Mary M. Migliorini, Allison L. Arai, Mashhood M. Wani, Simon Dujardin, Selen C. Muratoglu, Bradley T. Hyman, Dudley K. Strickland
This study shows LRP1 and SORL1 internalize and degrade tau, while also facilitating its cytosolic seeding, suggesting their role in tau pathology spread in Alzheimer's disease.
bioRxiv · Nov 17, 2020 · PreprintNeuroscience