Author

Simon Dujardin

Harvard UniversityORCID 0000-0002-5614-341XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Bradley T. HymaniD· 2 shared Abigail A. Obeng-MarnuiD· 1 shared Alexandra N. MillsiD· 1 shared Alexandra T. StariD· 1 shared Allison L. AraiiD· 1 shared Ana Claudia Silva AmaraliD· 1 shared Andreas NeuederiD· 1 shared Arsalan S. HaqqaniiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Bradley T. HymanORCID

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3 papers

Recent·Most cited

Neurosciencenpj Parkinson s DiseasePeer-reviewedAug 22, 2025

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

Sungwon An, John J. McInnis, Dongin Kim…·Can Kayatekin

This paper presents preclinical data on a bispecific antibody, SAR446159, designed to target alpha-synuclein aggregates and cross the blood-brain barrier for treating synucleinopathies.

23 citationstop 1%

mouserat

𝕏 PostBluesky

NeuroscienceMolecular NeurobiologyPeer-reviewedNov 10, 2021

Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

Tiziana Petrozziello, Evan A. Bordt, Alexandra N. Mills…·Ghazaleh Sadri‐Vakili

This study shows that reducing tau with a degrader prevents mitochondrial fragmentation and oxidative stress in ALS models.

49 citations

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 17, 2020

LRP1 and SORL1 regulate tau internalization and degradation and enhance tau seeding

Joanna M. Cooper, Aurélien Lathuilière, Mary M. Migliorini…·Dudley K. Strickland

This study shows LRP1 and SORL1 internalize and degrade tau, while also facilitating its cytosolic seeding, suggesting their role in tau pathology spread in Alzheimer's disease.

6 citations

humanproteomics

𝕏 PostBluesky