Endogenous labeling empowers accurate detection of m6A from single long reads of direct RNA sequencing
Wenbing Guo, Zhijun Ren, Xiang Huang, Jialiang He, Jie Zhang, Zehong Wu, Yang Guo, Zijun Zhang, Yixian Cun, Jinkai Wang
This paper introduces m6Aiso, a deep learning model that accurately detects m6A sites on single RNA molecules using endogenous labeling and DRS data, revealing new insights into m6A dynamics across RNA isoforms.
bioRxiv · Jan 30, 2024 · PreprintBioinformatics