Yang Guo

Decoder-FFPE-seq improves sensitivity and resolution for spatial transcriptomics in FFPE tissues, enabling analysis of rare genes and tumor microenvironments.

The paper develops HDAMS, a method that improves differential m6A site analysis by incorporating antibody specificity predictions, leading to more accurate and functionally relevant results.

This study identifies GAS6-AS1 as a key regulator of 5-FU resistance in CRC by stabilizing MCM3 mRNA through PCBP1 recruitment, suggesting it as a therapeutic target.

This paper introduces m6Aiso, a deep learning model that accurately detects m6A sites on single RNA molecules using endogenous labeling and DRS data, revealing new insights into m6A dynamics across RNA isoforms.