Mudan He

Translation control by maternal Nanog promotes oocyte maturation and early embryonic development

This study shows maternal Nanog controls oocyte maturation and early embryonic development by repressing eef1a1l2 transcription, which reduces translational activity and prevents ER stress.

A landscape of differentiated biological processes involved in the initiation of sex differentiation in zebrafish

This study identifies distinct biological processes in zebrafish gonad differentiation at 25 and 30 dpf, revealing metabolic and immune-related pathways in ovary and testis development respectively.

Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation

This study demonstrates the successful production of genome-edited sperm from a phylogenetically distant fish species using cross-subfamily spermatogonial stem cell transplantation.

Elovl2 but not Elovl5 is essential for the biosynthesis of docosahexaenoic acid (DHA) in zebrafish: insight from a comparative gene knockout study

This study shows Elovl2, not Elovl5, is essential for DHA synthesis in zebrafish, using gene knockout models and quantifying DHA levels in liver and embryos.

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors

This study shows Nanog represses maternal β-catenin activity by interfering with TCF factors, preventing hyper-dorsalization in early embryos.

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

This study develops a method combining CRISPR/Cas9 and PGC transplantation to efficiently generate maternal-zygotic mutants of embryonic lethal genes in zebrafish.