Molecular BiologybioRxivPreprint
TSC2-extracellular matrix crosstalk controls pulmonary vascular proliferation and pulmonary hypertension
Yuanjun Shen, Dmitry A. Goncharov, Andressa Z. Pena…·Elena A. Goncharova
This study shows TSC2 deficiency in pulmonary vascular smooth muscle cells leads to ECM remodeling, hyper-proliferation, and pulmonary hypertension, which can be reversed by restoring TSC2 function.