TSC2-extracellular matrix crosstalk controls pulmonary vascular proliferation and pulmonary hypertension
Yuanjun Shen, Dmitry A. Goncharov, Andressa Z. Pena, Jeffery Baust, Andres Chavez Barragan, Arnab Ray, Analise Rode, Timothy N. Bachman, Baojun Chang, Mauricio M. Rojas, Horace Michael DeLisser, Ana Lucia Mora, Tatiana V. Kudryashova, Elena A. Goncharova
This study shows TSC2 deficiency in pulmonary vascular smooth muscle cells leads to ECM remodeling, hyper-proliferation, and pulmonary hypertension, which can be reversed by restoring TSC2 function.
bioRxiv · Aug 10, 2021 · PreprintMolecular Biology