Hannah D. Holly

This paper introduces Priori, a method to predict transcription factor activity from RNA sequencing data, showing it outperforms existing methods in detecting aberrant activity and identifying disease-related factors.

The paper systematically examines mutation groupings in cancer genes to identify downstream expression programs and reveals functional divergence among mutations within the same gene.

The paper identifies mutual exclusivity patterns in de novo mutations in autism spectrum disorder, linking them to circadian clock and PI3K/AKT signaling pathways.