Author

William M. Yashar

Oregon Health & Science UniversityORCID 0000-0002-8850-9850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Theodore P. BrauniD· 3 shared Galip Gürkan YardımcıiD· 2 shared Julia E. MaxsoniD· 2 shared Akram TaherinasabiD· 1 shared Andrew AdeyiD· 1 shared Brittany M. CurtissiD· 1 shared Camilo Posso· 1 shared Chelsea HutchinsoniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioinformatics

Theodore P. BraunORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 23, 2026

PU.1 inhibition sensitizes stem-monocytic AML to BCL2 blockade

William M. Yashar, Itallia V. Pacentine, Akram Taherinasab…·Theodore P. Braun

This study identifies stem-monocytic AML as a distinct subtype resistant to venetoclax and shows that PU.1 inhibition synergizes with BCL2 blockade to enhance therapeutic response.

DOI 10.64898/2026.01.20.700677

humanscRNA-seq

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BioinformaticsbioRxivPreprintDec 16, 2022

Predicting transcription factor activity using prior biological information

Joseph Estabrook, William M. Yashar, Hannah D. Holly…·Emek Demir

This paper introduces Priori, a method to predict transcription factor activity from RNA sequencing data, showing it outperforms existing methods in detecting aberrant activity and identifying disease-related factors.

DOI 10.1101/2022.12.16.520295

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintJan 10, 2022

GoPeaks: Histone Modification Peak Calling for CUT&Tag

William M. Yashar, Garth Kong, Jake VanCampen…·Theodore P. Braun

GoPeaks is a peak calling method for CUT&Tag data that improves sensitivity in detecting H3K27Ac peaks compared to standard algorithms.

2 citations

ChIP-seqstatistical model

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