Emanuela Colombo

This study shows that NPMc+ and Flt3-ITD cooperate to create a new quiescent HSC state that supports leukemia transformation and stem cell maintenance.

GASOLINE detects germline and somatic structural variants from long-read sequencing data with high accuracy, outperforming existing methods in synthetic and real datasets.

The paper uses nanopore sequencing to map DNA methylation in AMLs, revealing hypermethylation at CpG-poor regions drives chemoresistance through transcription factor networks.