Pier Giuseppe Pelicci

Cell cycle control of chromatin creates a therapeutic window for epigenetic therapy in tumors

This paper shows that extending G1 phase in cancer cells creates a therapeutic window for epigenetic drugs, with LSD1 inhibition and CDK4/6 inhibition working synergistically to induce differentiation and improve survival in AML models.

MiTo: tracing the phenotypic evolution of somatic cell lineages via mitochondrial single-cell multi-omics

MiTo is a framework for analyzing mitochondrial single-cell lineage tracing data, outperforming existing methods in pre-processing and clonal inference, and providing insights into cell lineage and gene regulatory network heritability.

PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencing

PoreMeth2 identifies differentially methylated regions using Nanopore sequencing, revealing epigenomic changes in cancer and glial cells.

GASOLINE: detecting germline and somatic structural variants from long-reads data.

GASOLINE detects germline and somatic structural variants from long-read sequencing data with high accuracy, outperforming existing methods in synthetic and real datasets.

High-resolution Nanopore methylome-maps reveal random hyper-methylation at CpG-poor regions as driver of chemoresistance in leukemias.

The paper uses nanopore sequencing to map DNA methylation in AMLs, revealing hypermethylation at CpG-poor regions drives chemoresistance through transcription factor networks.

XenoCell: classification of cellular barcodes in single cell experiments from xenograft samples

XenoCell classifies host and graft cellular barcodes in xenograft single-cell datasets using a standalone tool.

Cerebro: Interactive visualization of scRNA-seq data

Cerebro is a desktop application for visualizing pre-processed scRNA-seq data, enabling non-expert users to explore and interact with their results through intuitive graphical interfaces.