Yueying He

Hypatia compares isoform complexities across cell populations using long-read single-cell transcriptomes, improving detection of isoform usage shifts and diversity.

This paper introduces LongFUSE, a tool for detecting fusion genes in single-cell long-read RNA sequencing data, showing improved accuracy over existing methods.

This study identifies NKX2-1-driven epigenetic and 3D chromatin remodeling as key to neuroendocrine prostate cancer progression and reveals CBP/p300 inhibitors as potential therapeutic targets.

The paper analyzes Hi-C data to show that chromatin contact networks in cancer and leukemia have reduced information transmission efficiency and shallower hierarchy compared to normal tissues.

The paper develops CTG, a diffusion-based method to improve Hi-C data reliability and reveal structural genomic regulation.

This study examines how CpG density distribution around transcription start sites influences gene transcription and regulation patterns in human genes.