Author

Cheng‐Han Lee

Academia SinicaORCID 0000-0003-2094-1222Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Abe Ernest Johann E Isagan· 1 shared Alain Morejon Morales· 1 shared Alexandra K. KiemeriD· 1 shared Anand KrishnaniD· 1 shared Andrew FreywaldiD· 1 shared Angie Chen· 1 shared Anjali SaxenaiD· 1 shared Anton Dmitriev· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Abe Ernest Johann E Isagan

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 1, 2026

Mild and Reversible Proprioception Perturbation Suggests Causal Biomechanics for Memory-Dependent Spatial Behavior in Mice

Meng-Xuan Liu, Nikky Chia-Ni Chang, Abe Ernest Johann E Isagan…·Ching-Lung Hsu

This study uses optogenetics to reversibly perturb proprioception in mice during spatial tasks, showing its role in path integration and spatial memory.

DOI 10.64898/2026.07.28.740838

mouseexperimental assay

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Cancer BiologyCell GenomicsPeer-reviewedMay 9, 2025

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

Chelsea E. Cunningham, Frederick S. Vizeacoumar, Yue Zhang…·Franco J. Vizeacoumar

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

8 citations

humanCRISPR screen

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