Ching-Lung Hsu

Mild and Reversible Proprioception Perturbation Suggests Causal Biomechanics for Memory-Dependent Spatial Behavior in Mice

This study uses optogenetics to reversibly perturb proprioception in mice during spatial tasks, showing its role in path integration and spatial memory.

Engineering a performance-improved, axon-targeted kalium channelrhodopsin for optogenetic neuropathway inhibition

The paper improves an optogenetic silencer for axonal inhibition, showing enhanced performance and axonal targeting in mouse models.

Ca2+ Plateau Potentials Reflect Cross-Theta Cortico-Hippocampal Input Dynamics and Acetylcholine for Rapid Formation of Efficient Place-Cell Code

The paper investigates the cellular mechanisms of BTSP-LTP in the hippocampus, showing that theta-oscillation-paced inputs and acetylcholine modulate Ca2+ plateau potentials for efficient place-cell coding.

CASTLE: a training-free foundation-model pipeline for cross-species behavioral classification

CASTLE is a training-free pipeline for cross-species behavioral classification that uses foundation models and ROI masking to achieve high accuracy without manual labeling.

Rapid synaptic plasticity contributes to a learned conjunctive code of position and choice-related information in the hippocampus

The paper shows that synaptic plasticity in hippocampal neurons helps form a conjunctive code of position and choice during learning.

Kilohertz two-photon fluorescence microscopy imaging of neural activity in vivo

This paper demonstrates ultrafast two-photon fluorescence microscopy for in vivo neural activity imaging at high spatiotemporal resolution in awake mice.

ShuTu: Open-Source Software for Efficient and Accurate Reconstruction of Dendritic Morphology

ShuTu is a software tool that enables efficient and accurate reconstruction of dendritic morphology from bright-field microscopy images through automated identification and manual correction.

MeCP2 nuclear dynamics in live neurons results from low and high affinity chromatin interactions

This study uses live-cell imaging to show MeCP2 has unique diffusion and chromatin binding kinetics in neurons, distinct from transcription factors and histones.