Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth D. Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ahmad Ansari, Rachel Pooley, Piers Wilkinson, Sarah Harper, Adam P. Butler, Euan A. Stronach, Julio Sáez-Rodríguez, Kosuke Yusa, Mathew J. Garnett
CRISPRcleanR reduces false positives in CRISPR-Cas9 screens by correcting gene-independent responses without assuming copy number status.
BMC Genomics · Aug 13, 2018Peer-reviewedBioinformatics