Dimitris Konstantopoulos

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

The paper develops a computational pipeline to enrich rare inhibitory neurons in scRNA-seq data, revealing three distinct modes of diversification in SST+ neurons during cortical development.

SCALA is a web-based tool for analyzing scRNA-seq and scATAC-seq data, offering integrated analysis and visualization of cell populations, trajectories, and regulatory networks.

The paper shows that continuous transcription initiation after DNA damage enhances repair of genes and regulatory regions by maintaining Pol II pause-release dynamics and chromatin accessibility.