Hongjie Yao

This study investigates R-loop dynamics during mouse early embryonic development and shows their role in regulating transcription during the maternal-to-zygotic transition.

This study uses hPSC-derived distal lung organoids to identify RAS cells as immune sentinels in human distal airways, revealing their roles in viral, bacterial responses, and COPD.

This study introduces RIAN-seq, a method for high-resolution R-loop detection, revealing clustered R-loops regulate gene expression in a number-dependent manner.

This study shows that a CTCF R567W mutation causes developmental disorders by altering 3D genome structure and neurodevelopmental pathways in mouse and human models.