Author

Chao Di

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Byung Ran SoiD· 2 shared Chie Arai· 2 shared Christopher C. VentersiD· 2 shared Gideon DreyfussiD· 2 shared Hongjie YaoiD· 2 shared Jingqi DuaniD· 2 shared Yaoyi LiiD· 2 shared Yingliang ShengiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

Byung Ran SoORCID

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Author profile →

4 papers

Recent·Most cited

R-loops orchestrate the maternal-to-zygotic transition by harnessing RNA polymerase II pause release

Yaoyi Li, Qing Li, Xinxiu Wang, Chao Di, Yingliang Sheng, Qingqing Cai, Sainan Huang, Jiayu Chen, Guangming Wu, Shaorong Gao, Hongjie Yao

This study investigates R-loop dynamics during mouse early embryonic development and shows their role in regulating transcription during the maternal-to-zygotic transition.

bioRxiv · Nov 3, 2025 · PreprintDevelopmental Biology

Capturing R-loops at base-pair resolution unveils clustered R-loops regulate gene expression in a number-dependent manner

Yaoyi Li, Yingliang Sheng, Chao Di, Hongjie Yao

This study introduces RIAN-seq, a method for high-resolution R-loop detection, revealing clustered R-loops regulate gene expression in a number-dependent manner.

bioRxiv · Feb 21, 2025 · PreprintMolecular Biology

TOMM40-APOE chimera linking Alzheimer's highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesis

Jinglei Xu, Jingqi Duan, Zhiqiang Cai, Chie Arai, Chao Di, Christopher C. Venters, Jian Xu, Maura Jones, Byung Ran So, Gideon Dreyfuss

The paper identifies a TOMM40-APOE chimera (T9A2) that links APOE4 to mitochondrial dysfunction and oxidative stress, suggesting a new pathway in Alzheimer's disease pathogenesis.

bioRxiv · Oct 9, 2024 · PreprintCell Biology

U1 snRNP regulates cancer cell migration and invasion

Jung‐Min Oh, Christopher C. Venters, Chao Di, Anna Maria Pinto, Lili Wan, Ihab Younis, Zhiqiang Cai, Chie Arai, Byung Ran So, Jingqi Duan, Gideon Dreyfuss

Moderate U1 snRNP inhibition raises cancer cell migration and invasion by up to 500% and shortens 3'UTRs in many genes, while U1 overexpression has the opposite effects.

Nature Communications · Jan 7, 2020Peer-reviewedMolecular Biology✦ In-depth digest