Huisheng Liu

This study shows that stage-adaptive integration of polydopamine coatings and nanoparticles enhances the maturation and secretory function of hPSC-derived alveolar organoids.

This study identifies PKM1-regulated PEP metabolism as a key factor in improving functional maturation of human stem-cell derived β cells by enhancing calcium response and insulin secretion.

This study identifies a mechanism by which UNC-13 in C. elegans regulates synaptic vesicle exocytosis through domain interactions and functional switches.

This study uses hPSC-derived distal lung organoids to identify RAS cells as immune sentinels in human distal airways, revealing their roles in viral, bacterial responses, and COPD.

This study shows that ECM stiffness influences site-specific lung development in organoids by directing cell differentiation and pathway activation.

This paper develops a novel peripherally acting alpha2A-adrenergic receptor antagonist, CDS479-2, which improves glucose control in diabetic mice without central side effects.

This study shows that a CTCF R567W mutation causes developmental disorders by altering 3D genome structure and neurodevelopmental pathways in mouse and human models.

This study identifies a CNV involving three enhancers that drive bilateral constricted ear malformations by coordinating HMX1 expression through distinct regulatory mechanisms.