Wei Kevin Zhang

This study identifies FXR as a suppressor of pulmonary fibrosis by interacting with PPP1CB to reduce SMAD2/3 phosphorylation, showing therapeutic potential with TERN101.

This study uses hPSC-derived distal lung organoids to identify RAS cells as immune sentinels in human distal airways, revealing their roles in viral, bacterial responses, and COPD.

The paper identifies a potent orally bioavailable SARS-CoV-2 PLpro inhibitor with in vitro and in vivo antiviral activity against SARS-CoV-2 and related coronaviruses.

This study shows that a CTCF R567W mutation causes developmental disorders by altering 3D genome structure and neurodevelopmental pathways in mouse and human models.