Author

Rylie M. Hightower

Children's of AlabamaORCID 0000-0003-2153-1735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Adrienne SamaniiD· 2 shared Andrea L. ReidiD· 2 shared David K. CrossmaniD· 2 shared Matthew S. AlexanderiD· 2 shared Michael A. LopeziD· 2 shared David Alan SchneideriD· 1 shared David I.H. Jee· 1 shared Douglas P. MillayiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetics

Adrienne SamaniORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintJun 14, 2021

miR-486 is an epigenetic modulator of Duchenne muscular dystrophy pathologies

Rylie M. Hightower, Adrienne Samani, Andrea L. Reid…·Matthew S. Alexander

The paper shows miR-486 is reduced in DMD muscles and its loss causes muscle and cardiac defects, identifying it as a driver of disease and a potential biomarker.

4 citations

mousebulk RNA-seq

GeneticsHuman Molecular GeneticsPeer-reviewedJul 31, 2020

DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies.

Andrea L. Reid, Yimin Wang, Adrienne Samani…·Matthew S. Alexander

This study investigates the role of DOCK3 in skeletal muscle and Duchenne muscular dystrophy, finding that reducing DOCK3 improves dystrophic muscle histology while complete loss worsens muscle function.

15 citations

mouseexperimental assay