David K. Crossman

This study uses single-nucleus RNA sequencing to identify epithelial transitional states and immune-epithelial communication changes after chlorine lung injury and shows mOGG1 remodels these states to promote recovery.

This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.

The paper shows that thalamic microglia engulfing synapses, driven by CD9 and FcγRIII signals, cause cognitive impairment after cortical injury.

This study investigates the role of DOCK7 in skeletal muscle and motor neurons, showing its regulation of WNT signaling and AChR clustering in both normal and DMD muscle.

This study develops alginate-based formulations of zebularine and retinoic acid for subcutaneous administration, promoting tissue regeneration and epigenetic changes in mice without adverse effects.

The paper identifies a BMP4-induced molecular signature in late-stage DMD skeletal muscle by comparing transcriptomes of DMD patients and BMP4-stimulated cells.

This study investigates the effects of conditional dystrophin ablation in skeletal muscle and brain, revealing functional deficits and pathway dysregulation in both tissues.

The paper shows that EV miRNAs from WT mice improve sociability in immunodeficient mice by modulating synaptic function and immune-neuron communication.

This study uses endoluminal tissue sampling to analyze genetic and transcriptional features of vein of Galen malformation endothelial cells.

The paper shows that DICER1 activity is essential for mitral valve development but not tricuspid valve development, revealing miRNA-mediated gene regulation as a differential mechanism.

This study develops a rodent model of rotational head trauma, identifies Cdk5 as a key mediator, and shows its inhibition reduces cognitive and pathological effects.

The paper shows miR-486 is reduced in DMD muscles and its loss causes muscle and cardiac defects, identifying it as a driver of disease and a potential biomarker.

This study shows that mitochondrial fission is essential for embryonic heart development by regulating ribosomal protein gene transcription through an AMPK-SIRT7-GABPB axis.

The paper investigates transcriptional changes in mouse myocardium during post-natal to adult transition, finding significant gene expression shifts and structural-functional adaptations.

This study investigates the role of DOCK3 in skeletal muscle and Duchenne muscular dystrophy, finding that reducing DOCK3 improves dystrophic muscle histology while complete loss worsens muscle function.

This study investigates the basal role of excess Nrf2 in regulating mRNA and miRNA interactions in the mouse myocardium using transgenic mice and high-throughput sequencing.