Xin Yang

This study shows that neuronal UBE3A loss triggers a TNF-driven neuron-to-microglia signaling axis that promotes synapse remodeling and microglial inflammation.

The paper identifies UBE3A-dependent regulation of oligodendroglial homeostasis via estrogen receptor-β signaling as a therapeutic target for Angelman syndrome.

This study identifies CHI3L1/YKL-40 as a stage-specific regulator of oligodendrocyte precursor cell (OPC) generation through IL13Rα2-mediated ferroptosis, limiting OPC production and affecting their maintenance.

The paper evaluates peptidomimetic inhibitors targeting TrkB/PSD-95 signaling in an Angelman Syndrome mouse model, showing improved seizure outcomes and cognition but not motor function.