Yu‐Wen Alvin Huang

This study shows that neuronal UBE3A loss triggers a TNF-driven neuron-to-microglia signaling axis that promotes synapse remodeling and microglial inflammation.

The paper identifies UBE3A-dependent regulation of oligodendroglial homeostasis via estrogen receptor-β signaling as a therapeutic target for Angelman syndrome.

This study identifies CHI3L1/YKL-40 as a stage-specific regulator of oligodendrocyte precursor cell (OPC) generation through IL13Rα2-mediated ferroptosis, limiting OPC production and affecting their maintenance.

The paper evaluates peptidomimetic inhibitors targeting TrkB/PSD-95 signaling in an Angelman Syndrome mouse model, showing improved seizure outcomes and cognition but not motor function.

This study validates that heterozygous NRXN1 deletions impair neurotransmitter release in human neurons across multiple labs, suggesting a human-specific synaptic dysfunction relevant for schizophrenia drug discovery.

The paper shows ApoE variants differentially affect neuronal signaling and synaptogenesis, mirroring their impact on Alzheimer’s disease risk.