Tadahiro Yamashita

This paper develops a paracrine factor local gradient system to create vascularized hepatocyte tissues that proliferate under perfusion.

This study shows that flow stimulation promotes capillary-scale vessel formation in hydrogels, while static conditions lead to endothelial-to-mesenchymal transition.

The paper introduces a new method combining USIM and AFM to measure stiffness and biomolecular distributions in 3D living tissue, revealing mechanical heterogeneity and the role of collagens.