Diana Sharysh

This study shows that loss of HIF1α in smooth muscle cells in atherosclerosis leads to oxidative stress, increased SMC proliferation, and plaque expansion.

The paper identifies conserved and species-specific mesenchymal cell populations in atherosclerotic lesions across mouse, pig, and human, using single-cell RNA sequencing data.

This study shows that physiological stretch reduces inflammation in cultured human aortic smooth muscle cells, while static culture or excessive stretch promotes an inflammatory, plaque-like state.

This study identifies 20 GWAS risk genes in smooth muscle cells linked to coronary artery disease and reveals shared disease mechanisms across different gene types.