Jacob Fog Bentzon

Loss of HIF1α signaling drives oxidative stress and expansion of smooth muscle cells in murine atherosclerosis

This study shows that loss of HIF1α in smooth muscle cells in atherosclerosis leads to oxidative stress, increased SMC proliferation, and plaque expansion.

Mouse, pig, and human atherosclerotic lesions have common and distinct mesenchymal cell populations

The paper identifies conserved and species-specific mesenchymal cell populations in atherosclerotic lesions across mouse, pig, and human, using single-cell RNA sequencing data.

Loss of physiological stretch elicits an inflammatory, plaque-like transcriptional state in cultured human aortic smooth muscle cells

This study shows that physiological stretch reduces inflammation in cultured human aortic smooth muscle cells, while static culture or excessive stretch promotes an inflammatory, plaque-like state.

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease

This study identifies 20 GWAS risk genes in smooth muscle cells linked to coronary artery disease and reveals shared disease mechanisms across different gene types.

MyD88-dependent signaling promotes smooth muscle cell phenotypic modulation and fibrous cap formation in murine atherosclerosis

This study shows that MyD88 promotes smooth muscle cell phenotypic modulation and fibrous cap formation in atherosclerosis by reducing cap SMC recruitment and preserving contractile phenotype.