Lise Filt Jensen

Loss of physiological stretch elicits an inflammatory, plaque-like transcriptional state in cultured human aortic smooth muscle cells

This study shows that physiological stretch reduces inflammation in cultured human aortic smooth muscle cells, while static culture or excessive stretch promotes an inflammatory, plaque-like state.

Mapping atherogenesis mechanisms in smooth muscle cells by targeting genes linked to coronary artery disease

This study identifies 20 GWAS risk genes in smooth muscle cells linked to coronary artery disease and reveals shared disease mechanisms across different gene types.

MyD88-dependent signaling promotes smooth muscle cell phenotypic modulation and fibrous cap formation in murine atherosclerosis

This study shows that MyD88 promotes smooth muscle cell phenotypic modulation and fibrous cap formation in atherosclerosis by reducing cap SMC recruitment and preserving contractile phenotype.