David O. Morgan

This study identifies intramolecular loops that regulate SARS-CoV-2 N-protein self-association and nucleic acid binding through phosphorylation-dependent conformational changes.

This study determines cryoEM structures of human separase in apo and substrate-bound forms, revealing substrate recognition mechanisms and cleavage regulation.

The paper shows that a phosphate-binding pocket on cyclin B influences CDK substrate phosphorylation and mitotic timing in budding yeast.