Synthetic BiologybioRxivPreprint
speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing
Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Fabrice S. Schlatter…·Sai T. Reddy
speedingCARs uses domain shuffling and single-cell sequencing to engineer CAR T cells, identifying effective variants with diverse transcriptional signatures and T cell phenotypes.