Author

Raphaël B. Di Roberto

ETH ZurichORCID 0000-0003-0976-5395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Rocío Castellanos-RuedaiD· 2 shared Sai T. ReddyiD· 2 shared Andreas R. HierlemanniD· 1 shared Andrew G Duncan· 1 shared Anthony MarchandiD· 1 shared Benita WolfiD· 1 shared Bruno E. CorreiaiD· 1 shared Darya PalianinaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSynthetic Biology

Rocío Castellanos-RuedaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Synthetic BiologyNature Chemical BiologyPeer-reviewedFeb 19, 2026

Drug-controlled CAR-T cells through the regulation of cell-cell interactions

Leo Scheller, Greta Maria Paola Giordano Attianese, Rocío Castellanos-Rueda…·Melita B. Irving

This paper develops DROP-CARs, drug-regulated CAR-T cells that control cell-cell interactions using small-molecule switches, showing in vitro and in vivo functionality.

2 citationstop 5%

humanexperimental assay

𝕏 PostBluesky

GeneticsG3 Genes Genomes GeneticsPeer-reviewedJan 24, 2025

A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells

Ian C. Tobias, Sakthi D. Moorthy, Virlana M. Shchuka…·Jennifer A. Mitchell

This study identifies a cis-regulatory enhancer cluster, SRR2-18, that regulates Sox2 transcription in mouse neural stem/progenitor cells, affecting their regional identity and differentiation into posterior neural fates.

11 citations

mousebulk RNA-seq

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintAug 23, 2021

speedingCARs: accelerating the engineering of CAR T cells by signaling domain shuffling and single-cell sequencing

Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Fabrice S. Schlatter…·Sai T. Reddy

speedingCARs uses domain shuffling and single-cell sequencing to engineer CAR T cells, identifying effective variants with diverse transcriptional signatures and T cell phenotypes.

4 citations

humanscRNA-seq

𝕏 PostBluesky