Iain Hepburn

The paper develops a biophysical model to show how synaptotagmin-1 and synaptotagmin-7 interact to shape synaptic release patterns through calcium binding and exocytotic kinetics.

This study shows that mammalian BK channels have higher unitary conductance, leading to more efficient calcium activation and stronger potassium currents compared to invertebrate channels.

The paper models the synaptic vesicle cycle with high spatial and molecular detail, showing dynamic recycling and regulation by synapsin-1 and tomosyn-1 during sustained activity.

The paper introduces a general vesicle modeling tool integrated into the STEPS software for simulating vesicle dynamics in cell models with realistic mesh reconstructions.

STEPS 4.0 improves scalability, performance, and memory efficiency for stochastic reaction-diffusion simulations of neurons.