Nihal Aly

The paper reports structures of GIRK1/4 channels with different stoichiometries and shows how subunit composition affects ligand binding and pharmacology.

This study reveals how asymmetric assembly of GIRK1/2 channels couples lipid-dependent gating to K+ permeation and pharmacological activation through structural and functional analyses.

This paper develops GAT1508-coated gold nanoparticles for detecting ER+ breast cancer cells through specific binding to GIRK1 channels, validated by flow cytometry and electrophysiology.