Georgios Skiniotis

This study characterizes GAT1508, a selective neuronal GIRK1/2 activator, showing superior antiepileptic efficacy and synergy with CBD.

The paper reports structures of GIRK1/4 channels with different stoichiometries and shows how subunit composition affects ligand binding and pharmacology.

This study reveals how asymmetric assembly of GIRK1/2 channels couples lipid-dependent gating to K+ permeation and pharmacological activation through structural and functional analyses.

This study investigates how ion species and milling voltage affect cryo-pFIB-SEM image quality, showing that optimal settings depend on specimen composition.

The paper analyzes depth-dependent structural damage caused by cryo-FIB milling using apoferritin as a reporter, showing damage varies with ion type and molecular target.

The paper uses computational and experimental methods to identify transition intermediates in the μ-opioid receptor-Gi protein complex that encode ligand efficacy.

This study uses library docking to identify subtype-selective CB2 receptor ligands, finding improved hit rates and affinities with larger libraries and structure-based optimization.

The paper uses cryo-EM to capture non-equilibrium states of the μ-opioid receptor bound to different ligands, revealing ligand-dependent conformational dynamics and G-protein activation differences.

The paper identifies ADGRL2's role in epidermal differentiation through Gα13 activation and structural interactions, using CRISPR, Perturb-seq, and cryo-EM.

The paper introduces a deep learning tool called Metric Ion Classification (MIC) to classify ions and waters in cryo-EM and x-ray crystallography structures, identifying mismodeled ions in the PDB.

This paper uses computational methods to model how nitazene derivatives bind to the mu-opioid receptor, identifying key binding modes and interactions.

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

The paper presents cryoEM structures of GIRK2 with and without cholesterol analog and PIP2, revealing how CHS modulates channel function by interacting with PIP2 in the transmembrane domain.

The paper presents structures of GABAB receptor dimers and homomers, revealing the role of ECL2 in ligand binding and G protein activation.