Mehreen Zaka

The paper reports structures of GIRK1/4 channels with different stoichiometries and shows how subunit composition affects ligand binding and pharmacology.

This study reveals how asymmetric assembly of GIRK1/2 channels couples lipid-dependent gating to K+ permeation and pharmacological activation through structural and functional analyses.

This paper develops GAT1508-coated gold nanoparticles for detecting ER+ breast cancer cells through specific binding to GIRK1 channels, validated by flow cytometry and electrophysiology.

This study identifies how PIP2 interacts with TMEM16A channels to activate them, revealing structural and functional insights for drug development.

This study develops ML-based QSAR models to screen small molecule libraries for novel anti-cancer therapeutics targeting IDH1 mutant receptors in glioblastoma.