Cancer BiologybioRxivPreprint
Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer
Élodie Roger, Hannah M Mummey, Eleni Zimmer…·Alexander Kleger
This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.